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No single gene is the causative agent
For the current prescription group, the average AUDIT-C score was approximately 5% lower than in the future-prescription group, a statistically significant difference
In a randomized, placebo-controlled Phase 2a trial, PP405 met its primary safety endpoint and secondary pharmacokinetic endpoint, showed no systemic absorption, and was well tolerated across a diverse patient population
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Funding This work was supported by the Hospital Fund Projects of the First Hospital of Lanzhou University (No.lldyyyn2021-7)
